乳腺癌钼靶X线钙化与HER-2/neu表达的关系及其意义
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    孙靖中


    Correlation between mammographic calcifications and HER-2/neu overexpression in breast carcinoma
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      目的:探讨乳腺癌钼靶X线钙化与HER-2/neu表达的关系及其临床意义。
      方法:分析152例乳腺癌钼靶X线片的钙化特点;并将切除的肿瘤标本行HER-2/neu检测,分析钼靶X线钙化特征与HER-2/neu表达之间的关系。结果:乳腺癌钼靶X线钙化组HER-2/neu过度表达率高于无钙化组(61.6% vs. 35.4%)(P<0.01);在73例钙化中,以钙化伴随毛刺征为主要表现者,HER-2/neu过度表达率高于单纯钙化组(P<0.05)。根据钙化形态特征,蠕虫状钙化组HER-2/neu过度表达率明显高于非蠕虫状钙化组(P=0.01)。钼靶X线钙化簇最大径≥25 mm者,多在HER-2/neu过度表达组(P<0.05),而钙化颗粒数≤20枚/cm2者,多在HER-2/neu阴性表达组(P<0.01)。
      结论:乳腺癌钼靶X线钙化与HER-2/neu过度表达关系密切,可为乳腺癌治疗策略的制定和预测预后提供参考。

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      Abstract:Objective:To evaluate the correlation between mammographic calcifications and HER-2/neu overexpression in breast carcinomas (BC) and its clinical significance.
      Methods :A retrospective study of preoperative mammograms in patients with breast carcinoma, and immunohistochemical staining of excised tumor specimens was carried out by using monoclonal antibody against HER-2/neu in 152 patients with BC to evaluate the correlation of mammographic calcifications with HER-2/neu overexpression.
      Results:There was a significant correlation between mammographic calcifications and HER-2/neu overexpression (P<0.01). In the 73 cases of carcinoma with calcifications on mammography, HER-2/neu overexpression was statistically higher in calcifications associated spiculated mass than in simple calcifications (P<0.05). According to morphologic aspects of calcifications, vermicular calcifications were more common in carcinomas with HER-2/neu overexpression than in those without HER-2/neu overexpression (P=0.01). The carcinomas with calcifications ≥25 mm in diameter were much more commonly associated with HER-2/neu overexpression (P<0.05), whereas the number of calcifications less than 20/cm2 was more common in HER-2/neu negative expression (P<0.01).
      Conclusions:Mammographic calcifications are significantly correlated with HER-2/neu overexpression and may offer reference for planning a therapeutic stategy and predicting prognosis of breast cancer.

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    王晓, 陈连胜, 田斌,孙涛,金广超,马国辉,臧益秀,孙靖中.乳腺癌钼靶X线钙化与HER-2/neu表达的关系及其意义[J].中国普通外科杂志,2008,17(5):10-439.
    DOI:10.7659/j. issn.1005-6947.2008.05.010

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    • 在线发布日期: 2008-05-25