Objective:To inverstigate the effect and safety of refractory intrahepatic and extrahepatic bile duct stones treated by choledochoscope holmium laser combined with electrohydraulic lithotripsy. Methods :The cllnical data of 67 cases of postoperative intrahepatic and extrahepatic bile duct stones treated with combined endoscopic holmium laser and electrohydraulic lithotripsy were analysed retrospectively. Results:After 1 to 7 times of biliary endoscopic holmium laser electrohydraulic lithotripsy treatment, 65 patients had complete removal of all residual stones with the success rate of 97%, and without complications. Conclusions:After holmium laser combined with electrohydraulic lithotripsy,the effect of choledochoscopic removal of intrahepatic and extrahepatic bile duct residual stones can be greatly improved It is a safe method for treatment of refractory intraand extrahepatic bile duct stones.