Abstract:Objective:To explore the expressions of survivin and Ki-67 in breast cancer tissues after neo-adjuvant chemotherapy and their clinical significance.
Methods :The expressions of survivin and Ki-67 in 60 cases of breast cancer with neo-adjuvant chemotherapy (NACT) with CTF regimen and 60 cases without NACT were detected by SABC immunohistochemical technique.
Results:The positive rates of survivin（36.7%）and Ki-67（38.3%） in neo-adjuvant chemotherapy group were significantly lower than those in control group（71.7%，61.7%）(P<0.05).There was a significantly positive relationship between the expression of survivin and Ki-67 in neo-adjuvant chemotherapy group(r= 0.47，P<0.05).The overall response rate of the neo-adjuvant chemotherapy was 73.3%.In neo-adjuvant chemotherapy group, the positive rate of survivin in partial remission (PR) cases（18.2%）was markedly lower than that in no respose (NC) cases（81.3%）(P<0.01).In neo-adjuvant chemotherapy group, the positive rate of Ki-67 in PR cases（47.7%）was lower than that in NC cases（56.3%）(P>0.05).
Conclusions:The therapeutic effect of neo-adjuvant chemotherapy with CTF regimen can increase the remission rate of breast cancer. Neo-adjuvant chemotherapy could inhibit the expression of survivin protein, and thus further inhibit proliferation of tumor cell.