Objective:To study the methods of diagnosis and treatment of acute mesenteric venous thrombosis (AMVT). Methods :The clinical data of 11 cases of AMVT were analyzed retrospectively. Computed tomography(CT) was diagnosed in 9 of 11 patients. Seven patients with AMVT were initially treated with anticoagulation and thrombolysis, while the other 4 patients underwent surgical operation. Results:Three of 11 patients died(mortality rate 27.3%). Seven patients were initially treated nonoperatively and one of them died(14.3%); 4 patients underwent surgical operation and two of them died(50%).Eight survivors were treated with long-term warfarin therapy. Seven of 8 patients survived in long-term (mean,64.7 mouths) and one patient had recurrence. Conclusions:CT scanning appears to be the first and primary diagnostic test of choice when AMVT is suspected. If diagnosed and treated early, AMVT is not likely to progress to cause gangrenous bowel and thus the mortality rate can be decreased. Long-term anticoagulant therapy can increase survival rate and has a low recurrence rate.