To evaluate the survival and prognostic factors of orthotopic liver transplantation (OLT) for hepatocellular carcinoma (HCC).
Methods :Eighty-nine HCC patients who underwent OLT in our hospital from August 2000 were followed up more than 6 months, and their clinical and follow up data were retrospectively analyzed.
Results:The 1-, 2-, and 3-year cumulative survival rate of the 89 patients was 91.2%，68.5% and 59.4% respectively. Univariate analysis revealed that the size, the presence of portal vein tumor thrombus, histological differentiation and pTNM stage were statistically significant factors affecting survival. Multivariate analysis using Cox proportional hazards regression model demonstrated that the size and the presence of portal vein tumor thrombus were independent and statistically significant factors affecting survival.
Conclusions:OLT is an effective treatment for HCC patients. Tumor diameter >5 cm, poor histological differentiation and high pTNM stage significantly affect the survival of these patients.