Objective:To investigate the value of quantitative assessment of hepatic fibrosis and indocyanine green measurement in predicting hepatic functional reserve in rats with liver cirrhosis.
Methods :Female Wister rats were divided into normal control and cirrhotic group,and cirrhotic models were established. Quantitative assessment of hepatic fibrosis was done by use of computer-assisted digital image analysis, and R15ICG was measured.
Results:Differences of R15ICG and quantitative assessment of hepatic fibrosis between the two groups at 8 and 10 weers after hepatic fibrosis model was established were statistically significant (P＜0.01). Quantitative assessment of hepatic fibrosis had a positive correlation（r=0.75 and 0.533，P＜0.05）with R15ICG and Child-Pugh score.
Conclusions:Combining quantitative assessment of hepatic fibrosis with indocyanine green measurement is helpful for total assessment of liver functional reserve.