ObjectiveTo investigate the effect of ursodeoxycholic acid（UDCA） on prevention of retrograde biliary tract infection after cholangioenterostomy.
MethodsFifty patients undergoing cholecystojejunostomy,cholangio-jejunostomy, pancreaticoduodenectomy and choledochoduodenostomy treated in our hospital, during a 2-year period, were randomly divided into control group and observation group, respectively. In addition to conventional postoperative care, control group received vitamin C, while UDCA was given to observation group. The incidence of postoperative retrograde infection of biliary tract in the two groups was compared. The duration of follow-up varied from 6 months to 2 years.
ResultsCompared with control group, The incidence of postoperative retrograde biliary tract infection in therapy group was significantly lower than that in comtrol group (4.0%vs.32.0%)(P＜0.05).
ConclusionsAdministration of UDCA following cholangioenterostomy is safe, and it can significantly reduce the occurrence rate of retrograde biliary tract infection.