胰十二指肠切除术后早期并发症危险因素分析及对策
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陈启龙

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Risk factors and treatment of early complications after pancreaticoduodenectomy
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    摘要:

    目的:探讨影响胰十二指肠切除术后早期并发症的危险因素和防治措施。
    方法:回顾分析10年间新疆医科大学第一附属医院行胰十二指肠切除术79例患者的临床资料。根据术后30 d内是否发生并发症将患者分为术后并发症组和术后无并发症组。分别对两组患者的临床特征、术前检查和手术相关因素进行比较分析。
    结果:全组术后并发症发生率为58.2%,病死率为13.9%。Logistic回归分析表明,术前血清胆红素水平、术前肝功能分级是术后早期并发症的独立危险因素(P<0.05)。年龄、血清清蛋白、空腹血糖、血红蛋白水平、术后是否给予肠内营养、肿块大小、肿块良恶性、胰肠吻合方式对手术后并发症发生率无明显影响;各指标的分组间差异无统计学意义(P>0.05)。
    结论:胰十二指肠切除术术后早期并发症的发生与患者术前血清胆红质水平和术前肝功能分级密切相关。恰当的围手术期处理可有效减少胰瘘等术后并发症的发生率。

    Abstract:

    Objective:To study the risk factors of early complications and methods of treatment after pancreaticoduodenectomy(PD).
    Methods:There were 79 patients who undercoent PD at our hospital between January 1998 and December 2007. All of the patients were divided into complication group and non-complication group according to the outcomes. Their clinical features, preoperative tests, and surgical factors were retrospectively analyzed.
    Results:The postoperative complication rate was 58.2%,and the hospital mortality was13.9%.Logistic regression showed that the level of total bilirubin and liver function classification were the independent risk factors(P<0.05).Age, serum-albumin level, fasting serum glucose, hemoglobin, giving enteral nutrition or not postoperatively, the size of tumor, benign or malignant tumor,and method of pancreaticojejunal anastomosis  had no relation with early  postoperative complications(P>0.05).
    Conclusions:The early complications after PD are closely related to the preoperative level of serum bilirubin and liver function. Proper periopertive management can effectively decrease the occurrence of pancreatic leakage and other postoperative compliccations.

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吴晓勇, 陈启龙.胰十二指肠切除术后早期并发症危险因素分析及对策[J].中国普通外科杂志,2009,18(9):904-908.
DOI:10.7659/j. issn.1005-6947.2009.09.004

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  • 收稿日期:2008-10-27
  • 最后修改日期:2009-05-31
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  • 在线发布日期: 2009-09-15