Objective:To investigate the diagnosis and treatment of insulinoma.
Methods:The clinical data of 33 patients with insulinoma were retrospectively analysed.
Results:The sensitivity of tumor localization with computed tomography scan(CT), magnetic resonance imaging(MRI), selective angiography(SAOG), preoperative ultrasonography(US), IRI/G and intraoperative ultrasonography（IOUS）, was 64.71%, 50%, 42.86%, 15.38%，94.74% and 100%, respectively. The pre-operative diagnosis rate was 54.55% in this series. Intraoperative positive palpation rate was 90.91%. Surgical enucleation was performed in 24 cases and distal pancreatectomy in 9 cases. The cure rate was 90.91%, the surgical complication rate was 33.33%，and the surgical mortality rate was 3.03%.
Conclusions:The topogaphic diagnosis by a combination of intraoperative palpation and IOUS is essential for selection of surgical treatment modalities and successful therapeutic efficacy in patients with insulinoma.