Objective:To investigate the choice of  different internal drainage procedures for the treatment of pancreatic pseudocyst.
Methods:The clinical data of 62 cases diagnosed as pancreatic pseudocyst and treated by surgical internal drainage in the past 13 years were retrospectively analyzed.
Results:The diagnosis of pancreatic pseudocyst was confirmed by B-US and/or CT before operation,and confirmed by  biopsy after operation in all of the cases. Thirty-one cases underwent Roux-en-Y cystojejunostomy with 9.7% incidence of postoperative infection of pseudocyst (3/31), 3.2% incidence of postoperative gastrointestinal bleeding(1/31), and no deaths. Sixteen cases underwent cystogastrostomy with12.5% incidence of postoperative infection of pseudocyst (2/16),  37.5% incidence of postoperative gastrointestinal bleeding(6/16), and 6.25% case fatality(1/16). Fifteen cases underwent sequential external and internal drainage with 6.7% incidence of postoperative infection of pseudocyst (1/15),  13.3% incidence of postoperative gastrointestinal bleeding(2/15), and no deaths.
Conclusions:Roux-en-Y cystojejunostomy is a safe and rational procedure for treatment of pancreatic pseudocyst. If the pseudocyst is suitable for cystogastrostomy, sequential external and internal drainage should be adopted instead of cystogastrostomy.