Objective: To study molecular biology and clinicopathologic characters of peritoneal metastasis of advanced gastric cancer and their relationship to prognosis.
Methods: Based on the molecular biology and the clinicopathologic characters and prognosis  single-factor analysis of relevant factors and risk assessment was made in  193 cases of gastric cancer.
Results: The younger the patient was with the earlier the time of occurrence of peritoneal metastasis of gastric cancer. There was a high expression of ICAM-1 and MMP-2, but low expression of TIMP-1 and p53 in gastric cancer patients with peritoneal metastasis.
Conclusions: ICAM-1,MMP-2,  TIMP-1 and p53 can well predict the occurrence of metastasis and the prognosis of patients with gastric cancer, and these factors can be used for preoperative assessment of the development of metastasis of gastric cancer.