Objective: To investigate the feasibility of biomedical fibrin glue in laparoscopic treatment of peptic ulcer perforation.
Methods: A total of 126 patients with peptic ulcer perforation were randomly divided into two groups (63 in each group).Biomedical fibrin glue was used in treatment group, and routine treatment was used in control group.The total volume of drainage after operation,rate of intestnial fistula and adhesions, allergy reaction,time of drainage tube removal,and average hospotal stay time were observed in both groups.
Results: There was no allergic reaction in treatment group.Total volume of drainage in treatment group was(65.3±7.5)mL,and (110.2±9.6)mL in control group,with a significant difference between the two groups(P<0.01).Four  fistula occurred in control group and none in treatment group (P<0.05).Time of drainage tube removal was (25.4±3.2)h in treatment group, and (49.4±3.5)h in control group (P<0.01).Average hospital stay time was (4.3±1.2)d in treatment group, and(6.5±1.4)d in control group (P<0.01).
Conclusions: Use of biomedical fibrin glue has a difinite effect on laparoscopic repair of peptic ulcer perforation; it can seal the injured site, promote ulcer healing and prevent gastric or intestinal leakage and intestinal adhesions, There are no allergic reactions associated with its use.