Objective: To observe the clinical effects and complications of laparoscopic Nissen fundoplication (LNF) in treatment of gastroesophageal reflux disease (GERD).
Methods:  From November 2006 to November 2008, 109 consecutive patients with GERD were treated by LNF. The clinical records of these patients were retrospectively analyzed.
Results: All patients, except one case converted to laparotomy because of bleeding from short gastric vessel.  The mean operation time was 〖JP2〗68.1 min (30-245 min); mean intraoperative blood loss was 30.0 mL (5-450 mL); and mean postoperative hospital stay was 4.2 d(2-8 d).Postoperatively, 102 patients were  followed-up for 3 to 27 months, and among them, 99 patients (97.1%) had complete resolution of their digestive symptoms such as regurgitation and heartburn, 2 patients (2.0%) had symptoms markedly relieved, and 1 patient (0.9%) had not improved. Postoperative complications included severe dysphagia in 2 cases, bloating in 1 case，diarrhea in 2 cases and postoperative hiatal hernia in 1 case.
Conclusions:  Laparoscopic Nissen fundoplication is a minimally-invasive, safe and effective procedure in the treatment of gastroesophageal reflux disease.