Objective:To explore the expression  and the significance of aquaporin 1 (AQP1) in breast carcinoma tissues.
Methods:Specimcns of breast carcinoma tissues of 40 cases and the non-cancerous adjacent tissues of 10 cases were obtained immediately after surgery, and expression of aquaporin1 in htese tissues was examined by RT-PCR technique.
Results:AQP1 mRNA expression level in breast tumor tissues was 0.8957±0.0428, that in non-cancerous adjacent tissues was 0.3401±0.0549, and there was significant difference between them (P＜0.05).
Conclusions:The expression of AQP1 is increased in breast carcinoma tissues compared to normal breast tissues.It suggests that AQP1 may be related to the growth and metastasis of breast carcinoma.