水通道蛋白1在乳腺癌组织中的表达及其意义
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王金泗

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Expression and significance of aquaporin-1 in breast carcinoma
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    摘要:

    目的:探讨水通道蛋白1(AQP1)在乳腺癌组织中的表达和意义。
    方法:取乳腺癌组织40例及癌旁组织10例,应用RT-PCR法检测AQP1 mRNA在乳腺癌和癌旁组织中的表达及分布。
    结果:乳腺癌中AQP1 mRNA表达量(0.8957±0.0428),明显高于癌旁组织AQP1 mRNA表达量(0.3401±0.0549),差异有统计学意义(P<0.05)。
    结论:AQP1在乳腺癌组织中表达增高,提示AQP1可能与乳腺癌生长、转移有关。

    Abstract:

    Objective:To explore the expression  and the significance of aquaporin 1 (AQP1) in breast carcinoma tissues.
    Methods:Specimcns of breast carcinoma tissues of 40 cases and the non-cancerous adjacent tissues of 10 cases were obtained immediately after surgery, and expression of aquaporin1 in htese tissues was examined by RT-PCR technique.
    Results:AQP1 mRNA expression level in breast tumor tissues was 0.8957±0.0428, that in non-cancerous adjacent tissues was 0.3401±0.0549, and there was significant difference between them (P<0.05).
    Conclusions:The expression of AQP1 is increased in breast carcinoma tissues compared to normal breast tissues.It suggests that AQP1 may be related to the growth and metastasis of breast carcinoma.

     

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王金泗, 林孟波.水通道蛋白1在乳腺癌组织中的表达及其意义[J].中国普通外科杂志,2009,18(11):1130-1131.
DOI:10.7659/j. issn.1005-6947.2009.11.006

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  • 收稿日期:2009-06-12
  • 最后修改日期:2009-10-12
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  • 在线发布日期: 2009-11-15