Objective: To investigate the weight loss mechanism of sleeve gastrectomy.
Methods: SD rats were fed with high-fat diet to induce obesity, and then the obesity rats were randomly divided into experimental group (underwent SG) and control group (underwent sham surgery).Eight weeks after operation, the body weight, food intake and peripheral blood concentration of Ghrelin, GLP-1, PYY3-36 of rats were checked.
Results: Compared with controll group, in experimental SG model, food intake was decreased (P＜0.05); the postoperative weight continued to decline for three weeks and then slowly recovered, and body weight was still lower than the preoperative 8 weeks later,while Ghrelin decreased and GLP-1, PYY3-36 increased (P＜0.05).With time, Ghrelin gradually increased and GLP-1, PYY3-36  gradually declined. In the control group,compared with peroperation, the postoperative weight markedly increased except one week after operation, and  8 weeks later, weight was significantly higher than preoperation; but food intake, Ghrelin, GLP-1 and PYY3-36 had no significant change (P＞ 0.05).
Conclusions: The weight loss of sleeve gastrectomy in DIO rats’s decline is lasting and obvious. The postoperative effect of decreased Ghrelin and increased GLP-1, PYY3-36 is the main mechanism for weight loss.