Objective：To analyze the prognostic factors in simultaneous resection of colorectal cancer （colon cancer and rectal cancer）and synchronous liver metastasis.
Methods：The prognosis of 37 patients with colorectal cancer and  synchronous liver metastasis who  received simultaneous resection were analyzed by multi-factorial logistic regression analysis.
Results：The age,the portal vein chemotherapy with local chemotherapy pump,histological classification,lymph node metastasis, and the location,size and number of metastatic lesions affected the survival time of the patients.
Conclusions：Intraoperative and postoperative chemotherapy through portal vein pump can improve prognosis and prolong median survival time in simultaneous resection colorectal cancer and synchronous liver metastasis, and it is an unique controllable factor.