高龄胃癌患者手术治疗效果观察及预后情况
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王正林 E-mail:wzl7623@yahoo.com.cn

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The outcome and prognosis of surgical treatment for gastric carcinoma in the elderly
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    摘要:

    目的:探讨高龄胃癌手术患者的临床病理特点、手术效果、并发症影响因素和预后。
    方法:回顾性分析手术治疗的80岁以上的高龄胃癌患者84例的临床资料。
    结果:I期10例(Ia期8例,Ib期2例),II期12例,Ⅲ期45例(53.6%),IV期17例。81%的患者存在一种或一种以上的合并症,主要为心血管疾病(43例,51.2%)。肿瘤切除率为85.7%(72/84),根治性切除率为60.7%(51/84)。51例根治性手术中,27例患者实施了D0/D1手术(52.9%),24例实施了D2手术(47.1%)。总的术后并发症为28.6%,手术相关并发症为6.0%;肺炎为最常见的非手术相关并发症(14.3%)。术后病死率为3.6%。肿瘤体积大小是影响术后并发症的独立危险因素(P=0.009)。根治性手术的总5年生存率为56.9%,其中D1手术的5年生存率为63.0%,D2手术的5年生存率为50.0%。I期胃癌5年生存率为80.0%。
    结论:对有轻微合并症的高龄胃癌患者(>80岁)行范围较小的淋巴结廓清手术是安全有效的,并可获得良好的预后。

    Abstract:

    Objective:To analyze the clinicopathologic features, effect of surgical treatment and prognosis of elderly patients with gastric cancer.
    Methods:The records of 84 elderly patients (aged 80 years or above) with gastric cancer who underwent operation in our hospital from 2000-2008 were analyzed retrospectively.
    Results:Ten patients had early gastric cancer (1a,8 cases, 1b, 2cases), stage II 12 cases, stage III 45 cases (53.6%) and stage IV 17 cases. Among them, 81% patients had one or more co-morbidities. Cardiovascular disease  was present in 43 cases(51.2%).  Resection rate was 85.7% (72/84).  Radical resection rate was 60.7%(51/84). Limited nodal dissection(<D2) was done in 27 cases (52.9%). D2 dissection was performed in 20 cases (47.1%).The postoperative complication rate was 28.6%, and the rate of surgical related morbidities was 6.0%. The main non-surgical complication in postoperative period was pulmonary infection (14.3%). The tumor size was an independent risk factor for postoperative complications (P=0.009).  Postoperative mortality was 3.6% (n=3).The 5 years survival rate was 63.0% for limited nodal dissection and 50.0% for D2 dissection.  Total survival rate for radical resection was 56.9%. The 5-year survival rate for stage I cancer was 80.0%.
    Conclusions:Gastrectomy with limited nodal dissection in elderly patients with gastric cancer and mild preoperative co-morbidity is safe and effective, and can achieve a good prognosis.   

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王正林|胡祥|梁品|田大宇.高龄胃癌患者手术治疗效果观察及预后情况[J].中国普通外科杂志,2010,19(4):386-391.
DOI:10.7659/j. issn.1005-6947.2010.04.014

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  • 收稿日期:2009-06-25
  • 最后修改日期:2009-12-31
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  • 在线发布日期: 2010-04-15