儿童甲状腺癌的临床特点和治疗
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周卫 E-mail:hhhliang@gmail.com

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Characteristics and treatment of childhood thyroid carcinoma
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    摘要:

    目的:探讨儿童甲状腺癌的临床病理特点及外科治疗方法。
    方法:回顾性分析1990年1月~2005年12月南昌大学第二附属医院手术治疗的26例儿童甲状腺癌患儿的临床病理资料、特点及治疗方法。
    结果:女性患儿15例,稍多于男性(11例)。患儿均经病理证实为甲状腺癌,其中乳头状癌14例,滤泡状癌9例,髓样癌2例,未分化癌1例。行肿瘤剔除手术1例;一侧腺叶及峡部切除加患侧中央区淋巴结清扫术5例,加单侧颈淋巴结清扫术15例;行甲状腺全切或近全切除加双侧颈淋巴结清扫术5例。颈淋巴结转移21例(80.8%)。术后3例患儿出现暂时性有症状性甲状旁腺机能减退,经治疗后缓解;全组未出现永久性甲状旁腺功能减退、无喉返神经麻痹及手术相关性死亡。5,7年总生存率为96.2%和91.6%。
    结论:儿童甲状腺癌多为分化型甲状腺癌,手术治疗后预后较好。

    Abstract:

    Objective:To investigate the clinicopathologic characteristics and therapy of thyroid carcinoma in children.
    Methods:A retrospective review of the clinical data of 26 childhood patients with thyroid carcinoma treated in the Second Affiliated Hospital, Nanchang University from Jan 1990 to Dec 2005 was conducted.

    Results:There were 15 girls and 11 boys in this series. All cases were diagnosed by histological evaluation: papillary carcinoma was diagnosed in 14, follicular carcinoma in 9, papillary follicular carcinoma in 2 and medullary carcinoma in 1. Cervical lymph node metastasis was found in 21 patients (80.8%). Among them, 1 underwent tumor enucleation, 5 underwent unilateral lobectomy and unilateral central compartment lymph node clearance, 15 underwent unilateral lobectomy and unilateral neck dissection, and 5 underwent neartotal or total thyroidectomy and bilateral neck dissection. All patients were followed up with tumor-free survival in 24 cases. The 5- and 7-year survival rate was 96.2% and 91.6%, respectively.Three patients required intravenous calcium supplementation postoperatively, but there was not a single case of permanent hypoparathyriodism or recurrent nerve paralysis during follow-up.
    Conclusions:Almost thyroid carcinoma in children are differentiated carcinomas,  the prognosis is significantly better after surgical treatment.

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黄亮| 周卫| 元云飞| 涂群飞| 张开华| 熊吉信.儿童甲状腺癌的临床特点和治疗[J].中国普通外科杂志,2010,19(11):1173-1176.
DOI:10.7659/j. issn.1005-6947.2010.11.002

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  • 收稿日期:2010-05-17
  • 最后修改日期:2010-10-11
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  • 在线发布日期: 2010-11-15