Objective：To review the clinical manifestations, pathology, diagnosis, and therapy of sclerosing angiomatoid nodular transformation(SANT) of spleen.
Methods：The clinical manifestations, pathology, expression of immunohistochemistry, and the  follow-up survey of 2 cases of SANT were  analyzed, and the related literature was reviewed.
Results：The morphological features of SANT under microscope were as follows: Multiple angioloma-like granuloma  nodules were observed. The nodules appeared as compact or mucoid-degenerated fibrous connective tissue, and tumour cells in the nodules were orbicular-ovate or short spindle-shaped with rich cytoplasm. Cladodromous or crack-like irregular capillary vessels were detected. There were numerous plasmocytes, lymphocytes, and erythrocytes in the interstitium. The cell morphology was mild with no-atypia, and  nuclear division was rarely seen. There were no specific immunological characteristics. The two cases of SANT had no relapse or metastasis during the 6-months to 1-year follow-up after splenectomy.
Conclusions：SANT is an infrequent hyperplatic and benign lesion of spleen which has a remarkably pathologic characteristic appearance. However, it might be mistdiagnosed clinically as other diseases, such as splenic cancer, inflammatory pseudotumor, hamartoma, etc. The effective therapy of SANT is splenectomy which has a good prognosis.