Objective：To explore the relationship between genetic polymorphism of MTRR and lower extremity deep venous thrombosis (DVT).
Methods：Polymorphism of the 66th site A/G of MTRR gene in disease group (n=101) and normal controls(n=120) was detected by polymerase chain reaction-sequence specific primer (PCR-SSP). The patients in the disease group were from the clinical cases which were diagnosed as DVT, and health examination adults were used as the normal control group.
Results：The 66th site of MTRR gene frequencies of AA，AG and GG genotypes was 26.76%, 43.66% and 29.58% in disease group, and 43.57%, 4.28% and 12.14% in normal controls, respectively. No significant difference was seen in the distribution frequency in two groups (χ2=3.22, P>0.05).
Conclusions：The distribution frequency of MTRR gene does not seem to be an independent genetic risik factor for deep venous thrombosis in China.