Objective：To investigate the protective effect of atractylodes macrocephalaon polysaccharide on ischemia-reperfusion（I/R）injury of liver in rats.
Methods：A total of 54 male SD rats were randomly divided into 3 groups: sham group, I/R group and  preconditional treatment of atractylodes macrocephalaon polysaccharide group (Group PC). The rats were killed at 1，6，24h after 60 mins of models conducted, and the serum ALT and AST level, the expression of ICAM-1 mRNA and IL-1 in liver tissue were observed.
Results：Compared with sham group, the ALT and AST levels,  the expression of ICAM-1 mRNA and IL-1 were significantly increased in PC and  I/R groups, but compared to I/R group, the ALT and AST levels and the expression of ICAM-1 mRNA and IL-1 in PC group were significantly decreased (P＜0.05).
Conclusions：Atractylodes macrocephalaon polysaccharide may have protection to ischemic injury of rat liver through reduction of ICAM-1 expression and  decrease production of IL-1.