Objective：To evaluate the value of CT perfusion imaging(CTP) for assessment of liver ischemia reperfusion injury (I/R) in a rabbit model using 256-slice spiral CT.
Methods：Rabbits underwent 60 min of left lobar ischemia and then were divided into 6, 12 and 24 h of reperfusion groups, and one sham operation group (n=6, for each group).All the rabbits were imaged with a CT perfusion protocol. The perfusion indices of hepatic arterial perfusion (HAP), hepatic portal perfusion (HPP), total liver perfusion (TLP) and hepatic perfusion index (HPI) were measured after obtaining perfusion index maps on workstation. Liver samples underwent histological examination after every group had completed scan workuop.
Results：(1) Heterogeneity of hepatic microvascular flow patterns appeared in the I/R 6, 12 and 24 h groups (low perfusion area or infarcted regions). (2) In infarcted regions of I/R groups, the HPP, TLP and HAP were lower than those of sham group except the HAP in I/R 6 h group, but HPI was higher compared to sham group. The perfusion parameters in the non-infarction area were declined. (3)There were significant differences in CT perfusion parameters between infarction and non-infarction area.
Conclusions：CTP can objectively and quantitatively reflect the alterations of liver hemodynamics in I/R injury.