Objective：To explore the experience on the diagnosis and treatment of hepatic focal nodular hyperplasia (FNH).
Methods：Clinical data of 31 FNH patients, including the clinical manifestations,laboratory tests, imaging, diagnosis and treatment, were studied retrospectively.
Results：Twenty-five cases (80.6%) were young adults (less than 40 years old). Most of the patients（74.2%，23/31） had no obvious symptoms, and HBsAg positive was only in one case. All the patients had normal liver functions, while AFP、CA19-9 and other tumor markers were within normal range. Twenty-seven patients had a single solitary focus and 4 had two lesions.Most of the lesions were located in hepatic segments  Ⅳ, Ⅴ and  Ⅷ. Lesion sizes ranged between 0.5 cm and 15.0 cm. The rate of diagnosis in this group was 3.2% by color Doppler ultrasound, 32.1% (9/28) by CT, 20% (2/10) by MRI, and 0% (0/3) by hepatic artery angiography. Correct preoperative diagnosis was made in only 3 cases (9.7%). Thirteen cases  (41.9%) were misdiagnosed as liver cancer, 4 misdiagnosed as hepatic adenoma, 2 misdiagnosed as hepatic hemangioma and 9 cases had indefinite diagnosis. Twenty-nine cases underwent hepatic resection, and 2 cases were treated conservatively after the diagnosis was confirmed by the comprehensive utilization of biopsy and imaging examinations. Follow-up time was 8 months to 6.5 years,and all the operated patients suffered no relapse. Two patients, who were treated conservatively, were followed up for 18 months to 53 months, and they were all alive, without significant changes in lesion sizes.
Conclusions：Most cases of FNH have no clinical symptoms, and an effective method to improve the diagnostic accuracy of FNH is by the comprehensive analysis of the imaging examinations.The patients suspected of FNH may undergo percutaneous biopsy and those symptomless patients who have a definite diagnosis of FNH, may be treated by regular and close observation.