Objective：To evaluate the feasibility of without using clips and harmonic scalpel and only using coagulation hook and absorbable suture to perform laparoscopic cholecystectomy(LC).
Methods：From December 2008 to June 2010, we performed  LC in  554 cases by using absorbable sutures instead of clips and harmonic scalpel to close the cystic duct and artery. First, we dissected the gallbladder by clamps and coagulation hook, and adopted an anterograde or retrograde LC according to the condition of Calot triangle. After the dissection of cystic duct and artery, their proximal ends were ligated with 10 cm long absorbable sutures, the knots were made intraperitonealy by clamps, and their distal ends were severed by coagulation hook.
Results：Except 2 cases, 1 case of gallbladder perforation making Calot triangle unclear and 1 case of gallbladder-colonic fistula formation, converted to open surgery, all the other cases successfully underwent LC. The mean operation time was 32 minutes (range 10 to 70 minutes). The blood loss ranged from 5 to 200 mL (mean,13 mL). there was no hemorrhage, biliary leakage or intra-abdominal infection post-operatvely. Among the patients, 503 cases were followed up for 1 month to 1.5 years (mean, 7 months), during which no abdominal pain, jaundice or fever occurred. 
Conclusions：Using absorbable sutures and coagulation hook  instead of clips and harmonic scalpel is a safe, reliable and more economical method for LC, and can avoid the complications caused by clips.