Objective:To explore the clinical efficacy of cholecystectomy plus Roux-en-Y gastric bypass operation on cholecystolithiasis patients with concomitant type 2 diabetes mellitus (T2DM).
Methods: Fifty-five cholecystolithiasis patients with concomitant T2DM, who were hospitalized from May 2008 to June 2010, underwent open or laparoscopic cholecystectomy combined with Roux-en-Y gastrojejunal bypass operation. All patients were followed up for one year period and their clinical data that included body mass index (BMI), fasting blood glucose (FBG), fasting serum insulin (FINS), homeostasis model assessment of insulin resistance (HOMA-IR) and glycosylated hemoglobin (HbA1c) before and after surgery as well as outcomes of the diabetes were analyzed.
Results:All 55 patients were cured of cholecystolithiasis. Of the patients, no significant changes were noted between the BMI values before and after operation (P＞0.05); at the first month after surgery, the FBG level showed a sustained and steadiely descending trend (P＜0.05); meanwhile, HbA1c level also decreased significantly (P＜0.05) with the postoperative glucose level and HOMA-IR was remarkably improved.
Conclusions:The combined procedures of cholecystectomy and Roux-en-Y gastrojejunal bypass operation not only cures cholecystolithiasis, but also has beneficial effects on T2DM.