Objective: To determine the value of repeat liver resection for recurrent colorectal liver metastases. Methods: The clinical data of 43 patients with recurrent colorectal liver metastases undergoing repeat liver resection and 67 patients with recurrent colorectal liver metastases undergoing systemic chemotherapy were retrospectively analyzed. Results: The 1-, 3- and 5-year survival rate of the repeat liver resection group was 83.7%, 51.1% and 27.9%, respectively, and of the chemotherapy group was 65.7%, 20.6% and 3.0%, respectively (P＜0.05 or P＜0.01). In the repeat liver resection group, no operative death occurred and the incidence rate of complications was 32.6%. Univariate analysis suggested that the number of recurrent liver metastasis, condition of the surgical margin, CEA level, tumor size and degree of tumor differentiation were related to the prognosis. Multivariate regression analysis revealed that only the number of recurrent liver metastasis and tumor size were independent risk factors for predicting the prognosis. Conclusions: Repeat liver resection is a safe treatment for patients with recurrent colorectal liver metastases, and is especially suitable for those with a low hepatic tumor load (tumor size less than 5 cm and metastases number fewer than 3). Repeat hepatectomy can prolong the survival of selected patients with recurrent colorectal liver metastases.