Objective: To investigate the feasibility and short-term efficacy of long stent grafting for treatment of long or multiple stenotic/occlusive lesions of femoropopliteal artery. Methods: Sixty patients (70 limbs) with femoropopliteal arteriosclerosis obliterans, who were admitted to our department from November 2008 to October 2010, underwent long self-expandable stents implantation (length of 8-20 cm) following dilation angioplasty of the stenotic/occlusive lesions with a long balloon. The patients (24 limbs) who had concomitant arteriosclerosis obliterans of infrapopliteal artery underwent dilation angioplasty using DEEP balloon at the same time. The technical success rate, complication incidence during and after surgery and clinical efficacy was observed. Results: The technical success rate of the balloon dilation plus long stents implantation in femoropopliteal artery was 94.3% (66/70 limbs), and the success rate of balloon dilation in infrapopliteal artery performed at the same time was 83.3% (20/24limbs). The patients′ clinical symptom improved and rest pain disappeared after operation. The ankle-brachial index (ABI) of the patients increased from 0.45 (0.44±0.20) before operation to 0.84 (0.86±0.24) after operation (P＜0.01). Only two cases showed intramuscular hematoma due to local rupture of the ectopic superficial femoral artery, but no other complications occurred. Conclusions: Long stents implantation is a minimally invasive, safe and effective method for treatment of long or multiple stenotic/occlusive lesions of femoropopliteal artery, but its long-term outcome needs to be further assessed.