Objective: To determine the clinical efficacy of laparoscopic surgery for treatment of gastroesophageal reflux disease (GERD). Methods: The clinical data from 33 patients undergoing laparoscopic repair of esophageal hiatal hernia and laparoscopic fundoplication from January 2008 to September 2011 were retrospectively analyzed. Of the patients, laparoscopic fundoplication (Toupét procedure) alone was performed in 5 cases, 25 cases underwent laparoscopic esophageal hiatal hernia repair plus a fundoplication (3 Nissen procedures and 22 Toupét procedures) and 3 cases had laparoscopic esophageal hiatal hernia repair alone. Results: The operations were successfully performed in all patients. The operatiive time was from 90 to 185 min and the average length of postoperative hospital stay was 6 days. There was no conversion to open procedure and no death occurred. No severe postoperative complications were observed. The postoperative follow-up period was from 1 month to 24 months. The symptoms of 32 patients completely disappeared, and 1 patient significantly improved. Conclusion: Laparoscopic repair of esophageal hiatal hernia and laparoscopic fundoplication are minimallyinvasive, safe and effective procedures for gastroesophageal reflux disease.