Objective: To analyze the hemodynamic features of lower extremity deep venous thrombosis (DVT) in different natural stages, so as to provide advices for treatment selection. Methods: The clinical data of 203 DVT patients admitted to our hospital during 3 years were retrospectively analyzed. The patients were divided into acute, subacute and chronic group based on their natural stages. For all the patients, the flow velocities, diameters of femoral and popliteal vein were measured by ultrasonography, and the hemodynamic parameters such as prothrombin time and blood fibrinogen were detected at the time of hospital admission. Results: Except for the popliteal vein diameter that showed no statistical difference among the 3 groups, other parameters such as femoral vein and popliteal vein flow velocity, femoral vein diameter, prothrombin time and blood fibrinogen were statistically different among the 3 groups (all P<0.05). In acute stage, the femoral and popliteal vein showed the slowest flow velocity, while the femoral vein showed the widest diameter and the blood showed a hypercoagulable state. In subacute and chronic stage, the femoral vein flow velocity increased, the vein diameter was reduced and the hypercoagulabe state was lessened. Conclusion: The hemodynamic state of lower extremity DVT presents a complex and changeable feature as its natural stages develop.