Objective: To investigate the clinical efficacy of endovascular treatment of subclavian steal syndrome (SSS). Methods: The clinical data of 86 patients with SSS undergoing endovascular treatment over the past 10 years were retrospectively analyzed. Of the patients, there were 11 cases of subclavian occlusion and 75 cases of subclavian stenosis (the stenosis degree of all the 75 cases greater than 70%). Results: Stents were deployed successfully in all patients and no intraprocedural complications occurred. Immediate postoperative angiography revealed that the stenotic or occlusive segments of the subclavian artery were patent and antegrade vertebral blood flow was restored. Arterial pulsations of the treated arm rapidly returned to normal and the differences in blood pressure between arms were less than 10 mmHg (1 mmHg=0.133 kPa). Follow-up was obtained in 72 patients with average period of 24 months. Of the follow-up patients, 2 cases died of malignant tumor, 4 cases died of myocardial infarction, and the symptoms of vertebral basilar insufficiency and upper extremity ischemia were improved or eliminated in the rest of the cases. The follow-up Doppler ultrasound examination showed that all the stents were patent and intact, with no evidence of stent migration. Conclusion: Endovascular treatment of SSS is safe and minimally invasive, with high success rate and good short-term efficacy. It should be the first choice of treatment for this condition.