Objective: To investigate the efficacy of B ultrasound-guided cryocycle microwave in adjuvant therapy for advanced liver cancer. Methods: One hundred and sixty-four consecutive patients with advanced liver cancer were randomly allocated either to study group or control group, with 82 cases in each group. Patients in both groups underwent embolization therapy, and then the patients in study group received, additionally, the B ultrasound-guided cryocycle microwave treatment. Results: Of the patients in study group, complete response was achieved in 12 cases, partial response was obtained in 40, stable disease was seen in 10 cases, progressive disease occurred in 20 cases, and overall response rate was 63.4% (52/82), while these parameters in control group occurred in 8, 22, 22, 30 cases and 36.6% (30/82), respectively. The efficacy in study group was better than that in control group and the overall rates between the two groups had statistical significance (χ2=5.760, P<0.05). The tumor deactivation rate was 97.6% in study group and 81.7% in control group, and the difference had statistical significance (χ2=6.852, P<0.05). All the patients had abdominal pain on the day after treatment, which disappeared without further special treatment, and no serious complications such as gastrointestinal perforation occurred in any of the patients. Conclusion: B ultrasound-guided cryocycle microwave combined with embolization therapy for advanced liver cancer is safe, effective and applicable, and deserves to be widely used.