Objective: To investigate the techniques and efficacy of the combined laparoscopic and endoscopic procedures in management of gallstones accompanied with common bile duct stones. Methods: The clinical data of 168 patients with concomitant gallbladder and common bile duct stones undergoing the combined treatment involving two procedures (laparoscopy plus choledochoscopy or duedenoscopy) or three procedures (laparoscopy plus choledochoscopy and duodenoscopy) during recent 6 years were retrospectively analyzed. Results: One hundred and twenty-six patients underwent the two combined procedures and three of them were converted to open surgery. Forty-two patients underwent the three combined procedures and two of them were comverted to open operation. There were no residual stones or serious complications, such as bleeding, biliary fistula or intra-abdominal infection, and no death occurred after operation. One hundred and twenty-four patients were followed up for 6 months, and no long-term complications, such as biliary stricture, were seen. Conclusion: The combined laparoscopic-endoscopic procedures are safe and feasible for concomitant gallstones and common bile duct stones, and reflect the minimally invasive orientation in modern surgical practice.