Objective: To systematically review the clinical efficacy of using fast-track surgery (FTS) in perioperative management of laparoscopic cholecystectomy. Methods: The literature concerning randomized controlled trials of laparoscopic cholecystectomy using FTS principles in online databases was retrieved. Data collection ended in July 2012. Then the literature was screened, data of the studies were extracted, qualities of the studies were evaluated and Meta analysis was performed. Results: A total of 8 studies with 1 060 patients were included. Compared with conventional group, FTS group had reduced length of hospital stay (MD=–2.36, 95%CI=–3.47— –1.25) (P<0.01), time to first postoperative passage of flatus (SMD=–3.04, 95%CI=–4.92— –1.16) (P<0.01) and incidence of lung infections (OR=–0.20, 95%CI=0.05–0.79) (P=0.02) as well as decreased hospital charges. Conclusion: FTS can enhance the rehabilitation of patient undergoing laparoscopic cholecystectomy. It deserves further investigation and spreading in clinical practice.