Abstract:Objective: To investigate the in?uence of concomitant Hashimoto’s thyroiditis on papillary thyroid carcinoma (PTC) lymphatic metastasis. Methods: The data of PTC patients undergoing surgical treatment within a period of 3 years were retrospectively analyzed and 224 cases meeting inclusion criteria were selected. Patients were divided into observation group (PTC with Hashimoto’s thyroiditis, n=45) and control group (PTC only, n=179), and the clinicopathologic profiles and status of lymphatic metastasis of the two group were compared. Results: The proportion of female patients and number of dissected lymph nodes in the central compartment in observation group were significantly higher than those in control group (both P<0.05). The differences in average numbers of metastatic lymph nodes in the central compartment and lateral neck between the two groups had no statistical significance (both P>0.05). Multiple regression analysis showed that concomitant Hashimoto’s thyroiditis was not associated with central and lateral neck metastasis in PTC patients (both P>0.05). Conclusion: Concomitant Hashimoto’s thyroiditis in PTC patients is not an independent predictive factor for cervical metastasis.