Objective: To investigate the ADAM23 and αvβ3 expressions in colorectal cancer and their relations with liver metastases and other clinicopathologic features. Methods: The protein and mRNA expressions of ADAM23 and αvβ3 in 53 specimens of colorectal cancer and their adjacent tissue, and 20 specimens of benign disease colorectal tissue were detected by immunohistochemical staining and RT-PCR method. The relations of their protein expressions with the clinicopathologic features were analyzed. Results: The positive expression rates of both ADAM23 protein and mRNA were significantly lower in colorectal cancer tissues than those in adjacent tissues and benign disease colorectal tissues (all P<0.05), whereas the positive expression rates of both αvβ3 protein and mRNA were significantly higher in colorectal cancer tissues than those in adjacent tissues and benign disease colorectal tissues (all P<0.05). There was a negative correlation between the protein expressions of ADAM23 and αvβ3 in colorectal cancer (χ2=10.3390; r=–0.637, P<0.01). The protein expressions of ADAM23 and αvβ3 were not related with age, sex, or degree of differentiation, but significantly associated with clinical stage, lymph node metastasis and liver metastasis (all P<0.05). In addition, ADAM23 protein expression was also relevant to depth of tumor infiltration (P<0.05). Conclusion: ADAM23 expression is decreased while αvβ3 expression is increased in colorectal cancer, and both are associated with colorectal cancer liver metastases and other unfavorable clinical outcomes.