腔内修复术与开腹手术治疗腹主动脉瘤围手术期疗效的Meta分析
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张建勇, Email: xjzyyzjy@sina.com

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Endovascular versus open repair for abdominal aortic aneurysms: a Meta-analysis of perioperative efficacy
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    目的:系统评价方法比较血管腔内修复术与开腹术手术治疗腹主动脉瘤(AAA)的围手术期疗效。方法:检索国内外文献数据库,收集血管腔内修复术与开腹术手术治疗AAA的随机对照试验,采用RevMan5.1软件进行Meta分析。结果:共纳入7个随机对照试验,8篇文献,共2 807例患者,其中行血管腔内修复术1?433例(腔内组),开腹手术1 374例(开腹组)。Meta分析结果显示,腔内组较开腹组手术时间减少(SMD=-0.87,95% CI=-1.43--0.31,P=0.002),术中输血量减少(SMD=-0.83,95% CI=-0.94--0.72,P<0.00001),ICU监护时间缩短(MD=-38.11,95% CI=-48.61--27.61,P<0.00001),术后住院时间缩短(MD=-5.11,95% CI=-6.26--3.95,P<0.00001),术后30 d病死例数降低(OR=0.30,95% CI=0.16-0.55,P=0.0001)。结论:腔内修复治疗AAA较开腹手术具有创伤小、失血少、术后恢复快的优点,围手术期具有较大优势,但长期预后有待研究。

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    Objective: To compare the perioperative efficacy of endovascular and open repair for AAA by means of systematic review. Methods: The literature of randomized controlled trials (RCTs) comparing endovascular and open repair for AAA was collected by searching the national and international databases. Meta-analysis was performed by using Revman 5.1 software. Results: Seven randomized controlled trials with 8 reports were included, which involved a total of 2?807 patients, of whom 1 433 cases underwent endovascular repair (endovascular group) and 1 374 cases underwent open surgery (open surgery group). Results of Meta-analyses showed that in endovascular group compared with open surgery group, the operative time and volume of intraoperative blood transfusion was reduced (SMD=–0.87, 95% CI=–1.43––0.31, P=0.002; SMD=–0.83, 95% CI=–0.94––0.72, P<0.00001), the length of postoperative stay in ICU and hospital was shortened (MD=–38.11, 95% CI=–48.61––27.61, P<0.00001; MD=–5.11, 95% CI=–6.26––3.95, P<0.00001), and number of 30-day postoperative death was decreased (OR=0.30, 95% CI=0.16–0.55, P=0.0001). Conclusion: Endovascular repair has the perioperative advantages of minimal trauma, reduced blood loss and quick postoperative recovery versus open surgery, but its long term results still need further observation.

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张建勇|孟德凯|时然然|陈辉|刘玉.腔内修复术与开腹手术治疗腹主动脉瘤围手术期疗效的Meta分析[J].中国普通外科杂志,2013,22(12):1562-1567.
DOI:10.7659/j. issn.1005-6947.2013.12.008

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  • 收稿日期:2013-05-06
  • 最后修改日期:2013-11-19
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  • 在线发布日期: 2013-12-15