Objective: To investigate the quality of life after non-surgical treatment of patients with lower extremity deep vein thrombosis (DVT) during a short period of observation. Methods: Fifty eligible lower extremity DVT patients were enrolled. Using SF-36 Health Survey Scale, the scores for 8 subscales of health dimensions that included physical functioning (PF), general health (GH), physical role (RP), emotional role (RE), social functioning (SF), bodily pain (BP), vitality (VT), and mental health (MH), were determined and compared in these patients before and at different time points (1 month, 2, 3, and more than 4 months) after treatment. Results: The base-line data of the patients were evenly distributed and comparable at different stages, average follow-up time was (3.82±1.84) months, and the overall Cronbach’s α coefficient for the scale was 0.8652. Of the patients, the scores for the 8 dimensions were all statistically different before and after standard treatment (all P<0.001), in which the scores at different stages after treatment were significantly higher than those measured before treatment, and were gradually increased with time prolongation. Except for the scores for PF dimension that were statistically different between the stages of 1 month and more than 4 months after treatment (P=0.01), all scores for the 8 dimensions showed no statistical difference (all P>0.05). Conclusion: In a short period after non-surgical treatment of lower extremity DVT patients, their quality of life can be markedly improved and then reach a plateau, and can even restore to a healthy condition. So, the inflection point in quality of life of these patients may be at any time beyond the first 4 months after treatment.