Objective: To investigate the diagnostic value of abnormal liver function parameters on the concomitant asymptomatic choledocholithiasis in cholecystolithiasis patients. Methods: The clinical data of 507 cholecystolithiasis patients undergoing surgical treatment were collected. The relations of the preoperative liver function parameters with the concomitant common bile duct stones were analyzed, and the receiver operating characteristic (ROC) curves for the significant parameters were generated to assess their sensitivities and specificities for diagnosis of the concomitant asymptomatic choledocholithiasis. Results: Except for total bilirubin (TBIL), the increases of the parameters that included the direct bilirubin (DBIL), alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (AKP), and γ-glutamyltransferase (GGT) in the patients were significantly related to the concomitant asymptomatic choledocholithiasis (P<0.05). The ROC curve analysis showed that area under the ROC curve of DBIL, ALT, AST, AKP and GGT was 0.548, 0.546, 0.584, 0.734 and 0.850, and their corresponding sensitivity was 46.4%, 33.3%, 48.8%, 72.6% and 75%, and specificity was 72.5%, 75.8%, 60.5%, 63.5% and 79.5%, respectively. Conclusion: Among the liver function parameters, the increased GGT level has the greatest value for the detection of cholecystolithiasis with concomitant asymptomatic choledocholithiasis.