Objective: To assess application value of bilateral water-dripping bipolar coagulation in hepatic lobectomy. Methods: The clinical data of 145 patients undergoing hepatic lobectomy in the first affiliated hospital of Chongqing Medical University between April 2011 and August 2013 were retrospectively analyzed. Of the patients, 93 cases underwent liver resection with bilateral water-dripping bipolar coagulation (observational group), and 52 cases received radiofrequency ablation (RFA)-assisted liver resection (control group). The clinical results of the two groups of patients were compared. Results: The preoperative data between the two groups were comparable, and all patients successfully received hepatic lobectomy. In observational group compared with control group, the operative time was prolonged, but the surgery-related cost and overall incidence of postoperative complications were significantly reduced (all P<0.05). There was no statistical difference between the two groups in terms of rate of first hepatic portal occlusion, intraoperative blood loss, transfusion rate, function recovery or length of postoperative hospital stay (all P>0.05). Conclusion: Hepatic lobectomy using bilateral water-dripping bipolar coagulation has the advantages of decreased postoperative complications and surgery-related cost, so it is recommended for use.