Objective: To investigate the clinical efficacy of iliac artery stenting plus femoral endarterectomy and patch angioplasty in treatment of multisegment iliofemoral arteriosclerosis obliterans. Methods: Forty patients with multisegment iliofemoral occlusion admitted from March 2010 to March 2013 were selected, and all of them underwent iliac artery stenting plus femoral endarterectomy and patch angioplasty. Results: Operation was successfully performed in all patients, and the clinical symptoms in 37 patients (92.5%) were significantly improved after treatment. The intermittent claudication distance and resting ankle-brachial index were significantly higher than those before operation (both P<0.05). The forty patients were followed-up for 12 to 45 months after operation; the primary patency rate was 70.0%, the assisted primary patency rate was 82.5%, and the second-stage patency rate was 92.5%, respectively. Statistical analyses showed that the primary patency rate in patients with Fontaine stage II disease was significantly higher than those with stage III and IV disease (P=0.039; 0.015), and no independent influential factor for the postoperative primary patency rate was found. Conclusion: Minimally invasive operation has demonstrable efficacy in treatment of multisegment iliofemoral arteriosclerosis obliterans, and it should be performed at the early stage of development of clinical symptoms so as to obtain the best primary patency rate.