Objective: To investigate the application value of associating liver partition and portal vein ligation in staged hepatectomy (ALPPS) for hepatocellular carcinoma (HCC) with post-hepatitic cirrhosis. Methods: The clinical data of one patient with HCC associated with hepatitis B virus (HBV) cirrhosis admitted in March 2014 to Xiangya Hospital of Central South University and undergoing ALPPS were retrospectively analyzed. Results: Preoperative assessment showed that the patient’s future liver remnant (FLR) to standard liver volume ratio was 20.2%. The patient underwent first-stage operation of right portal vein ligation and in situ splitting of the liver parenchyma, and then underwent a second-stage operation of right hemihepatectomy for tumor resection, on postoperative day (POD) 9, when the patient’s FLR to standard liver volume ratio reached 38.8% after the first-stage operation. For the first- and second-stage operation, the operative time was 255 min and 297 min, and the blood loss was 260 mL and 350 mL, respectively. The patient was discharged from the hospital on POD 21; no metastasis or recurrence occurred, and his HBV-DNA and AFP levels were within normal range during the 2-month follow-up period. Conclusion: For HCC patients with non-active HBV cirrhosis, a proper expansion of the indications for the ALPPS procedure is safe and feasible.