Owing to the lack of specific symptoms, the diagnosis of gallbladder carcinoma is often delayed, resulting in very poor prognosis. Increasing the incidence of early diagnosis of gallbladder carcinoma is critical for improving the prognosis of this disease, therefore the research of its biomarkers has become very important. The authors address the research progress in this field with the emphasis on serological biomarkers and molecular biomarkers of gallbladder carcinoma.