Objective: To evaluate the application value of the modified invagination pancreaticojejunostomy in pancreaticoduodenectomy (PD). Methods: The clinical data of 22 patients undergoing PD from February 2013 to October 2013 were retrospectively analyzed. Of the patients, 10 cases were subjected to traditional invagination pancreaticojejunostomy (traditional group) and 12 cases received the modified invagination pancreaticojejunostomy (modified group) during operation. The incidence of postoperative pancreatic fistula, operative time, intraoperative blood loss, and length of postoperative hospital stay between the two groups were compared. Results: The preoperative clinical data between the two groups were comparable. In modified group versus traditional group, the incidence of postoperative pancreatic fistula and operative time were significantly decreased (both P<0.05), while no statistical difference was noted in intraoperative blood loss and length of postoperative hospital stay (both P>0.05). Conclusion: Using modified invagination pancreaticojejunostomy in PD can reduce the incidence of postoperative pancreatic fistula and shorten the operative time, so it is recommended in clinical practice.