Objective: To analyze the clinical characteristics and outcomes of resectable breast cancer of different molecular subtypes in Uygur females. Methods: The data of 528 Uygur female patients with complete medical record, and initial diagnosis and surgical treatment in Affiliated Tumor Hospital of Xinjiang Medical University between January 2007 and April 2009 were collected. The clinical features, recurrence, metastasis and survival of different breast cancer subtypes were analyzed. Results: Among the 528 patients, 95 cases were luminal A subtype, 224 cases were luminal B subtype, 56 cases were HER-2-enriched subtype, and 153 cases were triple negative breast cancer (TNBC). In TNBC patients, the constituent ratios of cases with clinical stage III, age at onset equal to or less than 35 years, and number of axillary lymph nodes equal to or more than 4 were significantly higher than those in patients of other subtypes; the constituent ratio of cases with tumor size larger than 2 cm in patients with hormone-receptor-negative breast cancer was significantly higher than in those with hormone-receptor-positive breast cancer; the constituent ratio of HER-2-enriched subtype was significantly higher than other subtypes in group of patients aged from 36 to 65 years; the constituent ratio of cases having family history of malignant neoplasm in luminal B subtype patients was significantly higher than that in patients of other subtypes (all P<0.05). In patients with recurrence and metastasis, the visceral metastasis was frequently seen in HER-2-enriched subtype (16/27, 59.3%) and TNBC (55/94, 58.5%) cases, bone metastasis was mainly seen in cases of luminal A subtype (11/19, 60.0%), and the local recurrence rate in TNBC cases (6/94, 6.4%) was lower than that in cases of other subtypes. For patients of luminal A, luminal B, HER-2-enriched subtype and TNBC, the 5-year overall survival rate was 91.6%, 85.6%, 75.0% and 65.3%, and the 5-year disease-free survival rate was 83.1%, 75.9%, 55.4% and 44.4%, respectively. All the differences had statistical significance (all P<0.05). Conclusion: Among Uygur female breast cancer patients, luminal B is the most common molecular subtype, and those with luminal A subtype have a relatively good prognosis, while those with HER-2-enriched subtype and TNBC have an unfavorable outcome.