Objective: To systematically assess the safety and efficacy of using fast track surgery (FTS) technique in liver resection. Methods: The randomized controlled trials (RCTs) or clinical controlled trials (CCTs) concerning using fast-track surgery in hepatectomy were collected by searching several national and international databases. Data collection ended in October 2014. After screening for inclusion and data extraction, Meta-analysis was performed by the RevMan 5.2.3 software. Results: Five RCTs and 11 CCTs were finally included involving 1 529 patients, of whom 766 cases underwent hepatectomy with FTS protocol (FTS group) and 763 cases underwent hepatectomy with traditional perioperative management (control group). Meta-analysis results showed that in FTS group compared with the control group, the time to first postoperative flatus and food intake, as well as length of hospital stay were significantly shorter, hospitalization cost was significantly reduced, times for recovery of each of the liver function parameters and overall incidence of postoperative complications were all significantly decreased (all P<0.05). Conclusion: Application of FTS in hepatectomy is safe and effective, and it also can accelerate the postoperative recovery of patients.