Hypoxia inducible factor 2 (HIF-2) is a member of the basic helix-loop-helix/Per Arnt-Sim (bHLH-PAS) family, which can regulate the expressions of a variety of genes in response to intracellular hypoxia, and also closely related to tumor occurrence and development. Hepatocellular carcinoma (HCC) is one of the most common malignant tumors in China, with limited therapeutic options and high mortality. So, investigation of the role of HIF-2 in HCC may provide insights into improving treatment access and outcomes of the patients.