Objective: To investigate the cliniopathologic features, diagnosis and treatment of pancreatic neuroendocrine neoplasms (PNEN), so as to provide knowledge for further understanding of this condition. Methods: The clinical and pathological data of the 9 PNEN patients admitted in the First Affiliated Hospital of Anhui Medical University from December 2011 to December 2013 were retrospectively analyzed. Results: Of the 9 patients, 3 cases were male and 6 were female; all cases underwent ultrasound and CT examination, and 2 cases had MRI examination. The imaging examinations showed that the tumor was located in the head of the pancreas in 3 cases, neck of the pancreas in one case, the tail of the pancreas in one case, the body and tail of the pancreas in 3 cases, and body and tail of the pancreas with concomitant tumor in the diaphragmatic surface of the liver in one case. The 9 patients exhibited dissimilar clinical symptoms, of whom one case with islet cell tumor had typical symptoms of hypoglycemia such as dizziness and fatigue accompanied with drowsiness, hunger sensation and unconsciousness, and the other cases had no typical symptoms. All patients received surgical treatment, and their diagnoses were confirmed by postoperative pathological and immunohistochemical examinations. Conclusion: PNEN has low prevalence, insidious onset and usually without specific clinical signs and symptoms. Its diagnosis mainly relies on pathological biopsy and immunohistochemical staining, and surgery is the first option of treatment.