Objective: To determine the clinical efficacy of performing precise hepatectomy technique in surgery for intrahepatic stones. Methods: One-hundred and seven patients with intrahepatic stones admitted from March 2010 to December 2014 were selected, and were randomly assigned into observational group (54 cases undergoing precise liver resection) and control group (53 cases undergoing irregular liver resection). The relevant clinical variables between the two groups of patients were compared. Results: In observational group compared with control group, the operative time was prolonged (242.3 min vs. 203.4 min), but the intraoperative blood loss (361.3 mL vs. 518.6 mL), drainage volume during the day after surgery (131.7 mL vs. 208.6 mL), length of postoperative hospital stay (18.1 d vs. 20.9 d) and hospitalization expenses (22 000 yuan vs. 29 000 yuan) were reduced; the peak levels of transaminases on postoperative day 3 and 7 were decreased; the overall incidence of postoperative complications (5.56% vs. 18.87%) and stone recurrence rate (7.41 % vs. 20.75%) were lower, and all differences had statistical significance (all P<0.05). Conclusion: For patients with intrahepatic stones, performing precise hepatectomy can help alleviate surgical trauma, and reduce postoperative complications and stone recurrence rate.