Objective: To assess the therapeutic effect of radical resection of hepatic alveolar echinococcosis. Methods: The clinical data of 163 patients with hepatic alveolar echinococcosis undergoing radical surgical resection between January 2013 and June 2015 were analyzed retrospectively. Results: The average operative time for radical surgery was (3.1±1.2) h, and intraoperative blood loss was (763±498) mL. The median time for the retention of intraperitoneal drainage tube was 6 d, and 11 patients underwent T-tube drainage that was removed one month after operation. The mean time to first passage of flatus and oral intake was (2.1±0.8) d and (2.7±1.1) d, respectively, and length of postoperative hospitalization was (7.9±3.4) d. Postoperative complications occurred in 8 patients, which included bile leakage in 5 cases, surgical site infection in one case, and ascites in 2 cases. Telephone contact or outpatient clinic follow-up was conducted for one month to 6 months postoperatively, and no death or recurrent echinococcosis was reported. Conclusion: Radical resection is still the first treatment option for hepatic alveolar echinococcosis. Based on adequate preoperative evaluation of the feasibility, and knowledge about the intraoperative techniques such as hepatic blood flow control, liver anatomy, and portal vein and biliary reconstruction, radical surgical resection can improve the quality of life and extend the survival time of the patients.