Cirrhosis is a common chronic liver disease, and is associated with an increased incidence of gallbladder stones. The pathological profile of liver cirrhosis consists of two major aspects: portal hypertension and liver function decline, which may further cause local and systemic physiological changes, and play an important role in the pathogenesis of gallstone formation. In this paper, the authors address the pathological changes and pathogenesis of gallbladder stones associated with liver cirrhosis.